Substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic a

Details Substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic a Substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic a

1993-01-06

1994-11-15

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548236, 5483381, 5483097, 5483101, 5483425, C07D23354

Patent

active

053649443

ABSTRACT:
There are disclosed substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid derivatives and the pharmacologically acceptable salts thereof as inhibitors of PLA.sub.2 and lipoxygenase, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.

REFERENCES:
patent: 4268670 (1981-05-01), Wehling et al.
Chemical Abstracts, vol. 114, No. 25, Abstract 247, 270n, Jun. 24, 1991.
Chemical Abstracts, vol. 108, No. 23, Abstract 198, 210h, Jun. 6, 1988.
Cerrena et al., Coll. Czech Chem. Commun, 54(7) pp. 1966-1978, 1989.
Winkelmann et al. Arzneim-Forsch, 28(5) pp. 739-749, 1978.

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