Substituted benzoxazinorifamycin derivative and antibacterial ag

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514183, 540457, A61K 31535, C07D52100

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active

049652613

ABSTRACT:
A rifamycin derivative having the formula (I): ##STR1## wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, R.sup.2 is an alkyl group having 1 to 4 carbon atoms, and A is a group having the formula: ##STR2## in which n is an integer of 3 to 5, or group having the formula: ##STR3## in which R.sup.3 is a alkyl group having 1 to 5 carbon atoms; or a salt thereof. The rifamycin derivative (I) exhibits a strong antibacterial activity against Gram-positive bacteria and acid-fast bacteria, and also exhibits a strong antibacterial activity against tubercle bacilli.

REFERENCES:
patent: 4005077 (1977-01-01), Bickel et al.
patent: 4690919 (1987-09-01), Yamane et al.
patent: 4859661 (1989-08-01), Kano et al.

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