Substituted benzothienylpiperazines and their use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544362, 544363, 544373, 544376, A61K 31495, C07D40504

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active

058011765

ABSTRACT:
This invention relates to compounds of the formula ##STR1## wherein X is halogen, hydroxy, (C.sub.1 -C.sub.6)alkoxy, amino or trifluoromethyl; and
Y is --CN or --NR.sup.1 R.sup.2 ;
where
l is an integer of 0, 1 or 2;
m is an integer of 0, 1 or 2;
n is an integer of 2, 3 or 4, except when Y is CN, in which case n can also be 1;
R.sup.1 is hydrogen, (C.sub.1 -C.sub.6)alkyl or (C.sub.1 -C.sub.6)alkylcarbonyl;
R.sup.2 is hydrogen, (C.sub.1 -C.sub.10)alkylcarbonyl, (C.sub.3 -C.sub.12)cycloalkylcarbonyl, hydroxy-(C.sub.1 -C.sub.6)alkylcarbonyl, phenylcarbonyl, thienylcarbonyl or benzothienylcarbonyl;
or

REFERENCES:
patent: 4968792 (1990-11-01), Stack et al.
patent: 5240927 (1993-08-01), Hrib et al.
patent: 5395835 (1995-03-01), Glase et al.
patent: 5614524 (1997-03-01), Matassa et al.
patent: 5639764 (1997-06-01), Glamkowski et al.

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