Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2004-04-08
2008-10-28
Desai, Rita (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S454000
Reexamination Certificate
active
07442812
ABSTRACT:
The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof useful as Estrogen Receptor β agonists for treating Estrogen Receptor β mediated diseases such as benign prostatic hyperplasia.
REFERENCES:
patent: 6436923 (2002-08-01), Bhagwat et al.
patent: 6518301 (2003-02-01), Barlaam et al.
patent: 6593322 (2003-07-01), Bhagwat et al.
patent: 6630508 (2003-10-01), Dodge et al.
patent: 6794403 (2004-09-01), Malamas et al.
patent: 7217734 (2007-05-01), Dodge et al.
patent: 2 361 642 (2001-10-01), None
patent: WO 97/09348 (1996-09-01), None
patent: WO 99/02512 (1999-01-01), None
patent: WO 01/49673 (2001-07-01), None
patent: WO 01/64665 (2001-09-01), None
patent: WO 01/72713 (2001-10-01), None
patent: WO 03/044006 (2003-05-01), None
patent: WO 03/044006 (2003-05-01), None
patent: WO 03/015805 (2003-06-01), None
Anderson, et al., “Synthesis of 6,9-bisnormethyl-8-methoxy-12,13-epoxy-6,8,10-trichothec atriene,” Journal of Organic Chemistry, American Chemisal Society, Easton, U.S., vol. 42, No. 6, pp. 1045-1050 (1977).
Oude-Alink, et al., “Photolysis of 2-keto-2,3-dihydrobenzofurans, o-hydroxystyrenes and 1-o-hydroxyphenyl)-1,5-hexadienes,” Journal of Organic Chemistry, American Chemical Society, Easton, U.S., vol. 38, No. 11, pp. 1993-2001 (1973).
Shrestha, et al., “Facile synthesis of the fused 6-6-5 ring system containing chroman ring from 2-(1-hydroxy-5-alkenyl)phenol derivatives via intramolecular inverse-electron-demanddiels-alder reaction,” Bulletin of the Chemical Society of Japan, Japan Publications Trading Co., Tokyl, JP, vol. 72, No. 1, pp. 73-83 (1999).
Welhua, et al., “A role for estrogen receptor β in the regulation of growth of the ventral prostate,” PNAS, vol. 98, No. 11, pp. 6330-6335 (2001).
Mortensen, et al., “Synthesis and biological evaluation of a novel series of furans: ligands selectic for estrogen receptor α,” Journal of Medicinal Chemistry, A-K, Page Est. 10:8 (2001).
Meyers, “Estrogen receptor-β potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues,” Journal of Medicinal Chemistry, A-V, Page Est. 21:3 (2001).
Kuiper, et al., “Cloning of a novel estrogen receptor expressed in rat prostate and ovary,”Proc. Natl. Acad. Sci USA, vol. 93, pp. 5925-5930 (1996).
Tremblay, et al., “Cloning, Chromosomal Localization, and Functional Analysis of the Murine Estrogen Receptor β,”Molecular Endocrinology, vol. 11, No. 3, pp. 353-365 (1997).
Weihua, et al., “Estrogen receptor beta in the prostate,”Molecular and Cellular Endocrinology, vol. 193, pp. 1-5 (2002).
Korach, “Insights from the study of animals lacking functional estrogen receptor,”Science, vol. 266, pp. 1524-1527 (1994).
Krege, et al., “Generation and reproductive phenotypes of mice lacking estrogen receptor β,”Proc. Natl. Acad. Sci. USA, vol. 95, pp. 15677-15682 (1998).
Couse, et al., “Tissue distribution and quantitative analysis of estrogen receptor-α (ERα) and estrogen receptor-β (ERβ) messenger ribonucleic acid in the wild-type and ERα-knockout mouse,”Endocrinology, vol. 138, No. 11, pp. 4613-4621 (1997).
Meyers, et al., “Estrogen Receptor-b Potency-Selective Ligands: Structure-Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues,”J. Med. Chem., vol. 44, pp. 4230-4251 (2001).
Durst Gregory Lee
Norman Bryan Hurst
Richardson Timothy Ivo
Cleveland, Jr. John A.
Demeter John C.
Desai Rita
Eli Lilly and Company
Mabry John
LandOfFree
Substituted benzopyrans as selective estrogen receptor-beta... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted benzopyrans as selective estrogen receptor-beta..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted benzopyrans as selective estrogen receptor-beta... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4003606