Substituted benzonitriles

Details Substituted benzonitriles Substituted benzonitriles

1986-07-17

1987-06-30

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

544291, 558418, 558423, C07C12154, C07C12152

Patent

active

046772197

ABSTRACT:
An improved process for the preparation of 6-substituted-5-alkyl-2,4-quinazolinediamines, useful in the production of trimetrexate and similar antifolate agents, together with several novel intermediates are disclosed.

REFERENCES:
Elslager et al., "Chemical Abstracts", vol. 80, 1974, col. 48026s.
Elslager et al., "Chemical Abstracts", vol. 89, 1978, col. 89: 157152m.
Kienzle, "Chemical Abstracts", vol. 99, 1983, col. 99: 38484t.
McCullough et al., "Chemical Abstracts", vol. 87, 1977, col. 87: 95483t.
E. F. Elslager et al., J. Med. Chem., 26: 1753-1760 (1963).
W. L. F. Amarego, "Fused Pyrimidines-Part I, Quinazolines," Wiley Interscience, New York, 1967, pp. 330-332.
J. Davoll et al, J. Chem. Soc., Section C, (1970) 997-1002.

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