Substituted benzofurans and benzothiophenes, methods of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S230500, C514S337000, C514S314000, C514S443000, C514S275000, C514S259500, C514S249000, C514S243000, C514S248000, C514S367000, C514S394000, C514S303000, C514S301000, C544S105000, C544S183000, C544S236000, C544S279000, C544S331000, C544S350000, C546S122000, C546S113000, C546S114000, C546S118000, C546S174000, C546S281100, C548S159000, C548S194000, C548S305100, C549S051000, C549S057000, C549S058000

Reexamination Certificate

active

06872730

ABSTRACT:
The present invention relates to novel substituted benzofurans and benzothiophenes compounds that are antagonists of alpha V (αv) integrins, for example αvβ3and αvβ5integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by αvβ3and αvβ5integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula I:where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, m, n, i, j and k are defined herein.

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