Substituted benzoate derivatives

Details Substituted benzoate derivatives Substituted benzoate derivatives

1993-07-21

1995-12-05

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 27, 560 42, C07C22936, A61K 3124

Patent

active

054730961

ABSTRACT:
The present invention relates to the compounds of the formula: ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are independently hydrogen, lower alkyl which is optionally substituted, lower alkoxy which is optionally substituted, hydroxy, acyloxy, or halogen; R.sup.9 is hydrogen, hydroxy, acyloxy, lower alkyl which is optionally substituted, lower alkoxy which is optionally substituted, or lower alkylamino which is optionally substituted; E.sup.1 is hydrogen, or an ester residue; m is an integer of from 1 to 4;
or a pharmaceutically acceptable salt thereof. The compounds of the present invention exhibit phospholipase A.sub.2 inhibitory activity, and can be used in treating inflammatory conditions.

REFERENCES:
patent: 5011952 (1991-04-01), Yoshida et al.
Patent Abstracts of Japan, vol. 16, No. 449 (C-986), Sep. 18, 1992.
Patent Abstracts of Japan, vol. 16, No. 362 (C-971), Aug. 5, 1992.
Patent Abstracts of Japan, vol. 17, No. 309 (C-1070), Jun. 14, 1993.
Patent Abstracts of Japan, vol. 16, No. 449 (C-986), Sep. 18, 1992.

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