Substituted benzo[1,4]dioxines as antiobesity agents

Details Substituted benzo[1,4]dioxines as antiobesity agents Substituted benzo[1,4]dioxines as antiobesity agents

1999-06-01

2000-07-04

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31357

Patent

active

060839759

ABSTRACT:
This invention relates to novel substituted 1,4-benzodioxine compounds having antidiabetic, antihyperglycemic, and antiobesity properties represented by the formula ##STR1## wherein R.sup.1 and R.sup.6 are independently hydrogen, C.sub.1 to C.sub.6 alkyl, trifluoromethyl, cyano, C.sub.1 to C.sub.6 alkoxy, or halogen;

REFERENCES:
patent: 5061727 (1991-10-01), Bloom
patent: 5482971 (1996-01-01), Epstein
Bloom et al., J. Med. Chem. 1992, vol. 35, No. 16, pp. 3081-3084.
Bloom et al., Drugs of the Future, 1994, vol. 19(1), 23-26.
Emorine et al., Science, 1989, vol. 245, No. 8, pp. 1118-1121.
Largis et al., Drug Development Research, 1994, vol. 32, 69-76.

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