Substituted benzimidazoles and their use for inducing apoptosis

Details Substituted benzimidazoles and their use for inducing apoptosis Substituted benzimidazoles and their use for inducing apoptosis

2006-08-09

2008-09-09

Stockton, Laura L. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S265600

Reexamination Certificate

active

07423157

ABSTRACT:
The invention relates to compounds of formula (I)wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, R1is optionally substituted amino or hydroxy, and the substituents R2to R6have the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

REFERENCES:
patent: 6211177 (2001-04-01), Sperl et al.
patent: 6369092 (2002-04-01), Pamukcu et al.
patent: 2004/0214817 (2004-10-01), Pierce et al.
International Preliminary Report on Patentability issued for the corresponding PCT application No. PCT/EP2005/050586 on Aug. 14, 2006.

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