Substituted benzimidazoles and their use as PARP inhibitors

Details Substituted benzimidazoles and their use as PARP inhibitors Substituted benzimidazoles and their use as PARP inhibitors

2007-05-01

2007-05-01

Stockton, Laura L. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S211080, C514S253090, C514S254060, C514S316000, C514S394000, C540S575000, C544S364000, C544S370000, C546S187000, C546S199000, C548S306100

Reissue Patent

active

10935683

ABSTRACT:
Compounds of the formula Ia or IBwhereA is a saturated or monounsaturated heterocyclic, 4 - to 8-membered ring which contains one or two nitrogen atoms,and their tautomeric forms, possible enantiomeric and diastereomeric forms, their prodrugs and possible physiologically tolerated salts are useful as inhibitors of the enzyme poly(ADP-ribose)polymerase.

REFERENCES:
patent: 4093726 (1978-06-01), Winn et al.
patent: 5830905 (1998-11-01), Diana et al.
patent: 5877187 (1999-03-01), Orjales et al.
patent: 5958950 (1999-09-01), Padia et al.
patent: 5972980 (1999-10-01), Cornicelli et al.
patent: 6001866 (1999-12-01), Cornicelli et al.
patent: 6127384 (2000-10-01), Diana et al.
patent: 6303627 (2001-10-01), Koch et al.
patent: 1354554 (1971-08-01), None
patent: WO 97/04771 (1997-02-01), None
patent: WO 98/33802 (1998-08-01), None
Wahlgren, Curtis G. and Addison, Anthony W., Synthesis of Some Benzimidazole-, Ryridine- and Imidazole-Derived Chelating Agents, J. Heterocylic Chem., 26, 541 (1989), May-Jun. 1989, Chemistry Dept., Drezel University, Philadelia, PA.
Denny, William A., Newcastle, Gordon W. and Baguley, Bruce C., Potential Antitumor Agents. 59. Structure-Activity Relationships for 2-Phenylbenzimidazole-4-carboxamides, a New Class of “Minimal” DNA-Intercalating Agents Which May Not Act via Topoisomerase II, J. Med. Chem., 1990, vol. 33. No. 2, 815-819, University of Auckland School of Medicine, Auckland, New Zealand.
Orjales, Aurelio, Bordell, Maravillas and Rubio, Victor, Synthesis and Structure Activity Relationship of New Piperidinyl and Piperazinyl Derivatives as Antiallergics, J. Heterocylic Chem. 32, 707 (1995), Research Dept., FAES S.A. Bilboa, Spain.
Zarins, P., Lavinovich, E.S.; Arens, A and Germane, S., Abstract Substituted Piperidines were prepared by condensing piperidinecarboxylic acid with the corresponding o-HZC6H4NH2 at 220-50. degree. in polyphosphoric acid. Institute of Organic Synthesis, Academy of Sciences, Latvia S.S.R. U.S.S.R; CA 80: 146143, 1974.
Zarin, P.P., Lavrinovich, E.S. and Aren, A.K., Pyridinium Salts I. Reduction of 4-(Benzazol-2-yl) Pyridinium Salts in a Neutral Medium, UDC 547.821.3:547-822.1, Institute of Organic Synthesis, Academny of Sciences of the Latvian SSH, Riga. Jan., 1974.
Iemura, R., Kawashima, T., Fukuda, T., ITO, K. and Tsukamoto, T., Synthesis of Zensimidazole Derivatives as Potential H1-Antihistaminic Agents, J. Heterocyclic Chem. 24, 31 (1987), Jan.-Feb. 1987, Pharmaceuticals Reserach Center, Kanebo Ltd., 5-90, Tomobuchi-cho 1-Chome, Miyakojima-ku, Osaka, 534, Japan.

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