Substituted benzenesulfonylureas and thioureas process for their

Details Substituted benzenesulfonylureas and thioureas process for their Substituted benzenesulfonylureas and thioureas process for their

1996-09-03

1997-12-16

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514585, 514592, 514593, 514821, 564 23, 564 39, 564 40, 564 41, A61K 3117, C07C31158, C07C33542

Patent

active

056985967

ABSTRACT:
Substituted benzenesulfonylureas and -thioureas--processes for their preparation and their use as pharmaceuticals
Benzenesulfonylureas and -thioureas of the formula I ##STR1## where R(1) is H or (fluoro)methyl, R(2) is H, Hal or where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z is Hal, NO.sub.2 or alk(yl)oxy, are described.
The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.

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