Substituted benzenesulfonylureas and -thioureas-process for thei

Details Substituted benzenesulfonylureas and -thioureas-process for thei Substituted benzenesulfonylureas and -thioureas-process for thei

1996-11-07

1998-07-07

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514585, 514592, 514593, 514821, 564 23, 564 39, 564 40, 564 41, A61K 3117, C07C31158, C07C33542

Patent

active

057769800

ABSTRACT:
Benzenesulfonylureas and -thioureas of the formula I ##STR1## where R(1) is H or (fluoro)methyl, R(2) is H, Hal or where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z is Hal, NO.sub.2 or alk(yl)oxy, are described.
The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.

REFERENCES:
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patent: 5215985 (1993-06-01), Murphy et al.
patent: 5574069 (1996-11-01), Englert et al.
Linz et al., "Cardiovascular Effects of the Novel Potassium Channel Opener (3S,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-phensylsulfonylc hromane Hemihydrate", Arzneimittel-Forschung/Drug Research. 1992.

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