Substituted benzenesulfonylureas and -thioureas--process for the

Details Substituted benzenesulfonylureas and -thioureas--process for the Substituted benzenesulfonylureas and -thioureas--process for the

1998-05-19

2000-07-18

Kumar, Shailendra

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564 87, 564 88, 564166, 564170, 564176, 564177, 564185, 564186, C07C31116

Patent

active

060909811

ABSTRACT:
Benzenesulfonylureas and -thioureas of the formula I ##STR1## where R(1) is H or (fluoro)methyl, R(2) is H, Hal or (fluoro)(mercapto)alk(ozy)yl, E is O or S; Y is --[CR(3).sub.2 ].sub.n --, where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z in Hal, NO.sub.2 or alk(yl)oxy, are described.
The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.

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