Substituted benzenesulfonylureas and -thioureas, preparation pro

Details Substituted benzenesulfonylureas and -thioureas, preparation pro Substituted benzenesulfonylureas and -thioureas, preparation pro

1996-08-30

1998-03-24

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548472, A61K 3140, C07D20946

Patent

active

057313415

ABSTRACT:
Described herein are substituted benzenesulfonylureas and -thioureas of the formula (I): ##STR1## useful in treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrythmia. The compounds of formula (I) can be used as antiarrythmics and are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.

REFERENCES:
patent: 4379785 (1983-04-01), Weyer et al.
patent: 5416105 (1995-05-01), Satoh et al.
Fosset et al., "Identification, Mechanism of Function and Regulation of ATP-Sensitive Potassium Channels As Targets For Sulfonylureas Used in the Treatment of Type II Diabetes", Journ. Annu. Diabetol. Hotel-Dieu vol. 111, No. 21, Nov. 20, 1989. Chemical Abstract No. CA III:186728g.

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