Substituted benzenedicarboxylic acid diguanides, process for the

Details Substituted benzenedicarboxylic acid diguanides, process for the Substituted benzenedicarboxylic acid diguanides, process for the

1996-11-07

1998-03-24

Lambkin, Deborah

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564157, 564156, A61K 3116, C07C23367

Patent

active

057313504

ABSTRACT:
Benzenedicarboxylic acid diguanides of the formula I ##STR1## in which R(1) to R(5) have the meanings given in the claims, are useful antiarrhythmic pharmaceuticals having a cardioprotective component, even for the prevention of ischemically induced damage, in particular in the induction of ischemically induced cardiac arrhythmias. As a result of inhibition of the cellular Na.sup.+ /H.sup.+ exchange mechanism, they are used for the treatment of acute or chronic damage caused by ischemia. Moreover, they are distinguished by potent inhibitory action on the proliferation of cells. They are suitable for preventing the genesis of high blood pressure.

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