Substituted benzene derivatives useful as neuraminidase inhibito

Details Substituted benzene derivatives useful as neuraminidase inhibito Substituted benzene derivatives useful as neuraminidase inhibito

1995-03-30

1997-02-11

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

514381, 514535, 514538, 514541, 514542, 514544, 514562, 514563, 514564, 514565, 514567, 514568, 514625, 514634, 514635, 560 34, C07C27918, A61K 3119

Patent

active

056022778

ABSTRACT:
A compound of the Formula (I): ##STR1## or pharmaceutically-suitable salts or prodrug forms thereof, wherein: n is 0-1;

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Singh et al., Structure-Based Inhibitors of Influenza Virus Sialidase. A Benzoic Acid Lead With Novel Interaction, J. Med. Chem. 1995, vol. 38, No. 17, pp. 3217-3225.
Williams, et al., Synthesis And Influenza Neuraminidase Inhibitory Activity Of Aromatic Analogues of Sialic Acid, Bioorganic & Medicinal Chemistry Lasers, vol. 5, No. 19, pp. 2251-2254, 1995.
International Workshop on Sialidases from Viruses, Bacteria, Parasites and Mammalian Sources, Rigi Kaltbad Switzerland, Apr. 18-19, 1994, abstract from meeting, Ming Luo et al.

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