Substituted azetidinones as anti-inflammatory and antidegenerati

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

540360, C07D20508, A61K 31395

Patent

active

059523212

ABSTRACT:
New substituted azetidinones of the general Formula (I) which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described, wherein n is

REFERENCES:
patent: 4064120 (1977-12-01), Krapcho et al.
patent: 4115382 (1978-09-01), Krapcho et al.
patent: 4166907 (1979-09-01), Krapcho et al.
patent: 4174317 (1979-11-01), Krapcho
patent: 4260743 (1981-04-01), Bose
patent: 4510086 (1985-04-01), Ross et al.
patent: 4534896 (1985-08-01), Treuner et al.
patent: 4559335 (1985-12-01), Zahler
patent: 4576749 (1986-03-01), Zahler et al.
patent: 4680391 (1987-07-01), Firestone et al.
patent: 5104862 (1992-04-01), Durette et al.
patent: 5229381 (1993-07-01), Doherty et al.
patent: 5348953 (1994-09-01), Doherty et al.
Firestone Chem. Abstracts, vol. 115, No. 5 (Aug. 5, 1991) 41275e.
Firestone Tetrahedron, vol. 46 No. 7, pp. 2255-2262 (1990).
Yosifugi Chem. Abstracts, vol. 105 Abs. 97895t (1986).
Peitsch. Hartmut, Tetrahedron Letters No. 45 pp. 4053-4056 (1976).
Tanaka, et al Heterocycles vol. 24, No. 9, pp. 2539-2543 (1986).
Bories, et al, Cell vol. 59 pp. 959-968 (1989).
D. Campanelli, et al, J. Exp. Med., vol. 172, 1709-1714 (1990).
G. Jenne, et al., Nature 346, 570 (1990).
Kao, et al., J. Clin. Invest. 82: 1962-1973 (1988).
Labbaye, et al., Proc. Natl. Acad. Sci. USA. vol. 88, 9253-9256 (1991).
D. Rees, et al., Ped. Pulmon. Suppl. 9: 250, No. 178 (1993) "A Systemic Elastase Inhibitor Protects Rats Against Lung Injury from Instilled CF Sputum Sol".
J. B. Doherty, et al., Proc. Natl. Acad. Sci. USA, 90:8727-8731 (Sep. 93).
W.A. Hanlon, et al., Journ. of Leukocyte Biology, 50: 43-48 (1991).
J. Stolk, et al., Am. J. Respir. Cell Mol. Biol, 6:521-526 (1992).
D.S. Fletcher, et al., Am. Rev. Respir Dis, 141:672-677 (1990).
P. Birrer, et al., Am. J. Respir. Crit, Care Med. 150: 207-213 (1994).
G. M. Turino, Anals of the New York Academy of Sciences, 624: 18-29 (1991).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Substituted azetidinones as anti-inflammatory and antidegenerati does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted azetidinones as anti-inflammatory and antidegenerati, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted azetidinones as anti-inflammatory and antidegenerati will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1509877

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.