Substituted azaporphyrins as fluorescence labels

Details Substituted azaporphyrins as fluorescence labels Substituted azaporphyrins as fluorescence labels

2004-06-14

2008-05-13

Riley, Jezia (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S005000, C435S007100, C435S007200, C435S968000, C536S026600, C436S002000, C436S546000, C514S001000, C514S04400A

Reexamination Certificate

active

07371524

ABSTRACT:
The present invention relates to marker components, fluorescent probes, oligonucleotides, hybridization assays, and immunoassays using such products, and methods for making such products. According to the present invention, detectably labeled marker components are provided that comprise a fluorescent moiety coupled to two small solubilizing groups, one on each side of the molecular plane, said fluorescent moiety having substituents to control net charge so as to reduce or remove the problems of solvent sensitivity and nonspecific binding.

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