Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2011-08-30
2011-08-30
Wilson, James O. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C548S465000, C548S466000, C548S467000, C548S483000
Reexamination Certificate
active
08008491
ABSTRACT:
The present invention relates to a series of substituted aza-indole derivatives of the formula I:wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
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Eastwood Paul Robert
Jiang John Ziqi
Koehl Jack Roger
Mehdi Shujaath
Moorcroft Neil
Aventis Pharmaceuticals Inc.
Sackey Ebenezer O
Scully , Scott, Murphy & Presser, P.C.
Wilson James O.
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