Substituted (arylalkoxybenzyl)aminopropanamide derivatives and p

Details Substituted (arylalkoxybenzyl)aminopropanamide derivatives and p Substituted (arylalkoxybenzyl)aminopropanamide derivatives and p

1994-03-22

1995-08-29

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514618, 514617, 514619, 564162, 564163, 564164, 564165, 564167, 564168, 564171, A61K 31165, C07C23304

Patent

active

054460662

ABSTRACT:
The invention provides new compounds of formula (I) ##STR1## wherein, subject to a proviso, n is zero or an integer of 1 to 3; each of R and R.sub.1, which may be the same or different, is hydrogen, halogen, trifluoromethyl or C.sub.1 -C.sub.4 alkoxy; R.sub.2 is hydrogen or C.sub.1 -C.sub.4 alkyl optionally substituted by hydroxy; each of R.sub.3 and R.sub.4 independently is hydrogen or C.sub.1 -C.sub.4 alkyl; or a pharmaceutically acceptable salt thereof; and of formula (IA) ##STR2## wherein R.sub.5 is hydrogen, halogen, trifluoromethyl or C.sub.1 -C.sub.4 alkoxy, or a pharmaceutically acceptable salt thereof, which are active on the central nervous system (CNS) and can be used in therapy as anti-epileptics, anti-Parkinson, neuroprotective, antidepressant, anti-spastic and hypnotic agents.

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Eur. Neuropsychopharmacol. 1/ 317-319, 1991, P. Dostert, et al., "New Anticonvulsants With Selective MAO-B Inhibitory Activity".

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