Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-09-11
2007-09-11
Coleman, Brenda (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S444000
Reexamination Certificate
active
10715622
ABSTRACT:
Disclosed is the preparation and pharmaceutical use of substituted arylalcanoic acid derivatives of Formula I, wherein ring A, ring B, R1, R2, R3, R4, R5, X, Alk1, Alk2, Ar1, and Ar2are as defined in the specification. These compounds, as selective agonists activating peroxisome proliferator-activated receptors (PPAR), in particularly the RXR/PPARalpha, RXR/PPARgamma, and RXR/PPARdelta heterodimers, are useful in the treatment and/or prevention of type 2 diabetes and associated metabolic syndrome such as hypertension, obesity, insulin resistance, hyperlipidemia, hyperglycemia, hypercholesterolemia, atherosclerosis, coronary artery disease, and other cardiovascular disorders with improved side effects profile commonly associated with conventional PPARgamma agonists.
REFERENCES:
patent: 6054453 (2000-04-01), Lohray et al.
patent: 6353018 (2002-03-01), Jeppesen et al.
patent: 2003/0055076 (2003-03-01), Jeppesen et al.
patent: WO9919313 (1999-04-01), None
patent: WO 0008002 (2000-02-01), None
patent: WO 0023425 (2000-04-01), None
patent: WO0023451 (2000-04-01), None
patent: WO 0203415 (2000-04-01), None
patent: WO 0063190 (2000-10-01), None
patent: WO 0155085 (2001-08-01), None
patent: WO 03011834 (2003-02-01), None
Wilson et al., The PPARs: From Orphan Receptors to Drug Discovery, Journal of Medicinal Chemistry, vol. 43, No. 4, pp. 527-550, Feb. 2000.
Feb. 26, 2004 Search Report from corresponding International Application No. PCT/IB03/05371.
Deng Tuo
Li Zhi-bin
Liao Chenzhong
Liu Zhende
Lu Xian-Ping
Buchanan & Ingersoll & Rooney PC
Coleman Brenda
Research Institute of Tsinghua University
Shenzhen Chipscreen Biosciences Ltd.
LandOfFree
Substituted arylalcanoic acid derivatives as PPAR pan... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted arylalcanoic acid derivatives as PPAR pan..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted arylalcanoic acid derivatives as PPAR pan... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3783020