Substituted aryl 1, 4-pyrazine derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S405000

Reexamination Certificate

active

07041672

ABSTRACT:
Substituted aryl pyrazine derivatives of the formula I as defined herein,and their use in treating anxiety disorders, depression and stress related disorders are disclosed.

REFERENCES:
Richard B. Silverman, The Organic Chemistry of Drug Design and Drug Action, pp. 352-400. ® 1992 Academic Press, Inc.
Hans Bundgaard, Design of Prodrugs, p. 1. © 1985 Elsevier Science Publishers.
Al-Dabbagh and Smith, “Species differences in oxidative drug metabolism: some basic considerations.” Archives of toxicology. Supplement. Archiv fur Toxikologie. supplement, vol. 7, pp. 219-231 (1984).
Nakamura and Goto, “Synthesis and Chemiluminescence of 5-[(2-pyridyl)-, (2-pyrazinyl)-, and (substituted 2-pyrazinyl)amino]-1,24-trioxanes” Bulletin of the Chemical Society of Japan, vol. 61(10), pp. 3776-3778 (1988).
Shepard et al, “Pyrazine Diuretics. VI. (Pyrazincarboxamido)guanidines” Journal of Medicinal Chemistry, vol. 12(2), pp. 280-285 (1969).
Kehne and De Lombert, “Non-Peptidic CRF1 Receptor Antagonists for the Treatment of Anxiety, Depression and Stress Disorders” Current Drug Targets, vol. 1(5), pp. 467-493 (2002).

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