Substituted aromatic compounds

Details Substituted aromatic compounds Substituted aromatic compounds

1981-10-05

1984-12-04

Brust, Joseph Paul

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

544182, 424249, C07C12184

Patent

active

044863543

ABSTRACT:
The present invention provides compounds of the formula (III): ##STR1## or an acid addition salt thereof, wherein R.sup.6 is chlorine, bromine, iodine, C.sub.1-4 alkyl or trifluoromethyl, or R.sup.6 and R.sup.7 form a --CH.dbd.CH--CH.dbd.CH--group optionally substituted by a halogen atom or a C.sub.1-4 alkyl or trifluoromethyl group, R.sup.8 is hydrogen, bromine, iodine, C.sub.1-4 alkyl or trifluoromethyl, R.sup.9 is hydrogen, halogen, C.sub.1-4 alkyl or trifluoromethyl, R.sup.10 is hydrogen, methyl or fluorine and R.sup.11 is amino, C.sub.1-10 acylamino or di-substituted aminomethyleneamino provided that, at most, only two of R.sup.7 -R.sup.10 are other than hydrogen and that R.sup.7 -R.sup.10 are not all hydrogen when R.sup.6 is chlorine. Also provided are pharmaceutical compositions containing compounds of the formula (III), the first medical use of compounds of the formula (III), a process for preparing such compounds and intermediates through which this process proceeds.

REFERENCES:
patent: 2952677 (1960-09-01), Birtwell et al.
patent: 3637688 (1972-01-01), Rees et al.
patent: 4311701 (1982-01-01), Roth et al.
Rees, et al., J. of Med. Chem., 15, (1972), pp. 859-861.

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