Substituted aromatic compounds

Details Substituted aromatic compounds Substituted aromatic compounds

1984-02-27

1986-07-22

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544182, A61K 3153, C07D25306

Patent

active

046020179

ABSTRACT:
The present invention provides compounds of the formula (III): ##STR1## or an acid addition salt thereof, wherein R.sup.6 is chlorine, bromine, iodine, C.sub.1-4 alkyl or trifluoromethyl, or R.sup.6 and R.sup.7 from a --CH.dbd.CH--CH.dbd.CH-- group optionally substituted by a halogen atom or a C.sub.1-4 alkyl or trifluoromethyl group, R.sup.8 is hydrogen, bromine, iodine, C.sub.1-4 alkyl or trifluoromethyl, R.sup.9 is hydrogen, halogen, C.sub.1-4 alkyl or trifluoromethyl, R.sup.10 is hydrogen, methyl or fluorine and R.sup.11 is amino, C.sub.1-10 acylamino or di-substituted aminomethyleneamino provided that, at most, only two of R.sup.7 -R.sup.10 are other than hydrogen and that R.sup.7 -R.sup.10 are not all hydrogen when R.sup.6 is chlorine. Also provided are pharmaceutical compositions containing compounds of the formula (III), the first medical use of compounds of the formula (III), a process for preparing such compounds and intermediates through which this process proceeds.

REFERENCES:
patent: 2952677 (1960-09-01), Birtwell et al.
patent: 3637688 (1972-01-01), Rees et al.
patent: 4311701 (1982-01-01), Roth et al.
C.A., 48, (1954), Hitchings, et al., 2719i.
C.A., 51, (1957), Burroughs Wellcome, 9719e.
C.A. 53, (1959), Burroughs Wellcome, 7216h.
C.A. 53, (1959), Wellcome Foundation, 13186d.
C.A. 53, (1959), Winzler, et al., 14345h.
C.A. 55, (1961), Beyer, et al., 2676e.
C.A., 65, (1966), Settepani, et al., 52161f.
C.A., 68, (1968), Bitalla, et al., 104123n.
C.A., 74, (1971), Castland, et al., 99946a.
C.A., 76, (1972), Rees, et al., 113258c.
C.A., 77, (1972), Vorbrueggen, 48150r.
C.A., 68, (1968), Kittler, et al., 26976b.
C.A., 71, (1969), Heinisch, 49900y.
C.A., 74, (1971), Taylor, et al., 87927g.
C.A., 71, (1969), Hornyak, et al., 70570a.
C.A., 77, (1972), Rees, et al., 122123c.
C.A., 79, (1973), Vorbruegger, 66405y.
C.A., 85, (1976), March, et al., 180p.
C.A., 85, (1976), Neunhoeffer, et al., 21299z.
C.A., 85, (1976), Piskala, et al., 45598j.
C.A., 85, (1976), Hegarty, et al., 154151s.
C.A., 86, (1977), Wasti, et al., 43661j.
C.A., 86, (1977), Wasti, et al., 171386k.
C.A., 87, (1977), Hegarty, et al., 33694d.
C.A., 87, (1977), Hegarty, et al., 112003f.
C.A., 87, (1977), Berg, et al., 117366m.
C.A., 88, (1978), Neunhoeffer, et al., 121113q.
Rees, et al., J. of Med. Chem., 15, (1972), pp. 859-861.
Rosenberg, et al., Proc. Soc. Exp. Biol., (1964), 115, pp. 410-414.
Woodbury, et al., Arch. Int. Pharmacodyn., (1952), 92, pp. 97-107.

Affiliated with

Also associated with

Rating

Substituted aromatic compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted aromatic compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted aromatic compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-866237