Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1993-02-26
1995-06-13
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
546 22, 546 24, 548113, 548115, 548413, 549220, 549221, 558166, 558168, 558169, 558190, C07F 958, C07F 928, A61K 31675
Patent
active
054243033
ABSTRACT:
The present invention relates to novel aminophosphonate derivatives substituted in .alpha. position by phenol groups, of formula (I): ##STR1## in which: X.sup.1, X.sup.2, X.sup.3, R.sup.1, R.sup.2, A, B, Z and n are defined in claim 1, as well as their preparations and the pharmaceutical compositions comprising them.
REFERENCES:
Chemical Abstracts 1, vol. 84(9), 84:59666j, Mar. 1, 1976.
Chemical Abstracts II, vol. 85(15), 85:108717h, Oct. 11, 1976.
Chemical Abstracts III, vol. 107, (11), 111:96790j, Sep. 14, 1987.
"High Density Lipoprotein As a Protective Factor Against Coronary Heart Disease", The American Journal of Medicine, vol. 62, T. Gordon et al., pp. 707-717, May 1977.
"The influence of changes in lipid values induced by cholestryamine and diet on progression of coronary artery disease": results of the NHLBI Type 11 Coronary Intervention Study, (Feb. 1984) vol. 69, No. 2, 1984, By R. Levy et al., pp. 325-337.
"Helsinki Health Study: Primary Prevention Trial with Gemfibrozil in Middle-Ages Men with Dyslipidemia", The New England Journal of Medicine, vol. 317, No. 20, Nov. 1987, By M. Frick et al.
"Beneficial Effects of Combined Colestipol-Niacin Therapy on coronary Atherosclerosis and Coronary Venous Bypass Grafts", Journal of American Medicine, vol. 257, No. 23, Jun. 1987, By D. Blacnkenhorn et al., pp. 3233-3240.
Metabolism of Lipoproteins and Their Role in the Pathogenesis of "Atherosclerosis", Atherosclerosis Reviews, vol. 18, 1988, By D. Steinberg, pp. 1-23.
"Antiatherogenic effect of probucol unrelated to its hypocholesterolemic . . . ", vol. 84, Nov. 1987, Medical Sciences, By T. Carew et al. pp. 7725-7729.
"Probucol prevents the progression of atherosclerosis in Watanabe Heritable . . . ", Medical Sciences, vol. 84, Aug. 1987, By T. Kita et al., pp. 5928-5931.
"Effects of Probucol on Xanthomata Regression in Familian Hypercholesterolemia", Am. J. Cardiol., vol. 57, 1986, By A. Yamamoto et al., pp. 29-35.
"Phospha-Pharmaka", Nachr. Chem. Tech. Lab., o. 35, No. 10, 1987, By K. Issleib, pp. 1037-1042.
"Effects of fenofibrate, gemfibrozil and nicotinic acid on plasma lipoprotein levels in normal and hyperlipidemic mice", Atherosclerosis, vol. 70, 1988, By P. Olivier et al., pp. 107-114.
"Membrane Effects of Vitamin E. Deficiency: Bioenergetic and Surface Charge Deisity Studies of Skeletal Muscle and Liver Mitochondria", Ann. N.Y. Acad. Sci., vol. 393, 1982, By A. Quintanilha et al., pp. 32-47.
"Assay for Serum Lipid Peroxide Level and its Clinical Significance, Lipid Peroxides in Biology and Medicine", By K. Yagi, pp. 223-242, 1982.
Bentzen Craig L.
Guyon-Gellin Yves
Nguyen Lan M.
Niesor Eric
Phan Hieu T.
Rotman Alan L.
Symphar SA
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