Substituted aminophenylalkyl ketones, their preparation and use

Details Substituted aminophenylalkyl ketones, their preparation and use Substituted aminophenylalkyl ketones, their preparation and use

1983-07-11

1985-09-03

Warren, Charles F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564433, C07C 8750

Patent

active

045394296

ABSTRACT:
Novel lower-alkyl 2-(hydroxyphenylamino)phenyl ketones, useful as inhibitors of lipoxygenase activity, are of the formula ##STR1## wherein R is hydrogen, lower-alkyl, lower-alkoxy or halo; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and Alk is lower-alkyl. The compounds are prepared by de-etherification of the corresponding alkyl or benzyl ethers which are in turn prepared by reacting a 2-(alkoxy- or benzyloxyphenylamino)benzoic acid with an alkyllithium.

REFERENCES:
patent: 2075359 (1937-03-01), Salzberg et al.
patent: 3432507 (1969-03-01), Paquette
Wagner & Zook; Synthetic Organic Chemistry (Wiley & Sons 1953) pp. 171-172.
CA: 67, 81925p, (1967), J. R. Geigy A.G.

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