Substituted aminomethanediphosphonic acids and use in medicament

Details Substituted aminomethanediphosphonic acids and use in medicament Substituted aminomethanediphosphonic acids and use in medicament

1989-05-19

1991-10-15

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 93, 514 94, 514 95, 548113, 548119, A61K 31675, C07F 96506, C07F 9653, C07F 96539

Patent

active

050575058

ABSTRACT:
Heteroarylaminomethanediphosphonic acids of the formula ##STR1## in which R.sub.1 represents an optionally benzo- or cyclohexeno-fused 5-membered heteroaryl radical that contains, as hetero atom(s), either from 2 to 4 N-atoms or 1 or 2 N-atoms as well as 1 O-atom or S-atom and that is unsubstituted or is substituted by lower alkyl; by phenyl that is unsubstituted or is substituted by lower alkyl, lower alkoxy and/or by halogen; by lower alkoxy; by hydroxy; by di-lower alkylamino; by lower alkylthio and/or by halogen; and R.sub.2 represents hydrogen or lower alkyl, and their salts, have a regulatory action on the calcium metabolism and can be used as active ingredients in medicaments for the treatment of illnesses that can be attributed to disorders of the calcium metabolism. They are manufactured, for example, as follows: in a compound of the formula ##STR2## in which X.sub.1 represents a functionally modified phosphono group X and X.sub.2 represents phosphono or similarly represents a functionally modified phosphono group X, the group(s) X is(are) converted into free phosphono.

REFERENCES:
patent: 4687767 (1987-08-01), Bosies et al.
Chem. Abstr. 93:181017z (1980).
Derwent Abstract of Japanese J55089-293 (1980).

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