Substituted aminoalkylphosphinic acids

Details Substituted aminoalkylphosphinic acids Substituted aminoalkylphosphinic acids

1995-06-05

1996-10-22

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus acids or salts thereof

C07F 930

Patent

active

055678408

ABSTRACT:
P-substituted aminoalkylphosphinic acids of the formula ##STR1## wherein R denotes an optionally fluorinated methyl group, R.sub.1 denotes hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen or a fluorinated methyl group and R.sub.2 and R.sub.3 denote hydrogen or R.sub.2 denotes hydroxy, lower alkoxy or halogen and R.sub.3 is hydrogen or R.sub.2 and R.sub.3 together represent an oxo group, and their pharmaceutically acceptable salts are active as GABA.sub.B -agonists and can be used in the treatment of spinal spasticity, multiple sclerosis and cerebral palsy, trigeminus neuralgia, drug withdrawal syndromes and/or conditions of pain. They can be manufactured by methods known per se and suitable such methods are described.

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