Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus acids or salts thereof
Patent
1992-04-22
1994-01-25
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus acids or salts thereof
558166, 558169, C07F 930, C07F 928, A61K 3166
Patent
active
052817474
ABSTRACT:
P-substituted aminoalkylphosphinic acids of the formula ##STR1## wherein R denotes an optionally fluorinated methyl group, R.sub.1 denotes hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen or a fluorinated methyl group and R.sub.2 and R.sub.3 denote hydrogen or R.sub.2 denotes hydroxy, lower alkoxy or halogen and R.sub.3 is hydrogen or R.sub.2 and R.sub.3 together represent an oxo group, and their pharmaceutically acceptable salts are active as GABA.sub.B.sup.- agonists and can be used in the treatment of spinal spasticity, multiple sclerosis and cerebral palsy, trigeminus neuralgia, drug withdrawal syndromes and/or conditions of pain. They can be manufactured by methods known per se and suitable such methods are described.
REFERENCES:
patent: 3812221 (1974-05-01), Broder et al.
patent: 4656298 (1987-04-01), Dingwall et al.
patent: 5190934 (1993-03-01), Mickel et al.
patent: 5229379 (1993-07-01), Marescaux et al.
Frostl Wolfgang
Hall Roger G.
Maier Ludwig
Ciba-Geigy Corporation
Dees Jos,e G.
Fishman Irving M.
Frazier B.
Kaiser Karen G.
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