Substituted aminoalkanoylaminoalkyl phosphonate angiotensin conv

Details Substituted aminoalkanoylaminoalkyl phosphonate angiotensin conv Substituted aminoalkanoylaminoalkyl phosphonate angiotensin conv

1987-05-20

1989-07-18

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

514 85, 514 89, 514 90, 514 91, 514 94, 548413, 548406, 544 57, 544337, A61K 3140, A61K 31535, C07D20709, C07D29500

Patent

active

048494143

ABSTRACT:
Compounds of the formula ##STR1## wherein X is various amino or imino acids and esters are disclosed. These compounds are useful as anti-hypertensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.

REFERENCES:
patent: 4452790 (1984-06-01), Karanewsky et al.
patent: 4555506 (1985-11-01), Karanewsky et al.
patent: 4616005 (1986-10-01), Karanewsky et al.
patent: 4634689 (1987-01-01), Witkowski et al.
patent: 4670422 (1987-06-01), Karnanewsky et al.
patent: 4716155 (1987-12-01), Karanewsky et al.
Almquist et al., "Synthesis and Biological Activity. . . " J. Med. Chem., vol. 28, pp. 1062-1066 (1985).
Almquist et al., "Synthesis and Biological Activity. . . " J. Med. Chem., vol. 28, pp. 1067-1071 (1985).

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