Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-06-07
1998-05-12
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514653, 564182, 564355, 564361, A61K 31165, A61K 31135, C07C23335, C07C21520
Patent
active
057505756
ABSTRACT:
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl, alkenyl or alkynyl of up to twenty carbon atoms in length or --(CH.sub.2).sub.w R.sub.5. If R.sub.1 or R.sub.2 is --(CH.sub.2).sub.w R.sub.5, w may be an integer from one to twenty and R.sub.5 may be an hydroxyl, halo, C.sub.1-8 alkoxyl group or a substituted or unsubstituted carbocycle or heterocycle. Alternatively, R.sub.1 and R.sub.2 may jointly form a substituted or unsubstituted, saturated or unsaturated heterocycle having from four to eight carbon atoms, N being a hetero atom of the resulting heterocyle. R.sub.3 may be either hydrogen or C.sub.1-3. In the compounds, a total sum of carbon atoms comprising R.sub.1 or R.sub.2, (CH.sub.2).sub.n and (CH.sub.2).sub.m does not exceed forty. R.sub.4 is a carbocycle comprising a substituted or unsubstituted ring system, the ring system having a single ring or two fused rings, a ring comprising from three to seven ring atoms. The disclosed compounds are effective agents to inhibit undesirable responses to cell stimuli.
REFERENCES:
patent: 3124579 (1964-03-01), Yoshida et al.
patent: 3422107 (1969-01-01), Mohler et al.
patent: 3737433 (1973-06-01), Mohler et al.
patent: 4515795 (1985-05-01), Hinze et al.
patent: 4576947 (1986-03-01), Hinze et al.
patent: 4636507 (1987-01-01), Kreutzer et al.
patent: 4668786 (1987-05-01), Thiele et al.
patent: 4833146 (1989-05-01), Gebert et al.
patent: 4965271 (1990-10-01), Mandell et al.
patent: 5039666 (1991-08-01), Novick, Jr.
patent: 5096906 (1992-03-01), Mandell et al.
patent: B13737433 (1987-03-01), Mohler et al.
Fuhrer et al., ".beta.--Adrenergic Blocking Agents: Substituted Phenylalkanolamines. Effect of Side-Chain Length on .beta.Blocking Potency InVitro." J. Med. Chem. vol. 27, 1984 p. 831.
Bianco et al., Blood, 76:Supplement 1 (522), p. 133a, "Pentoxifylline (PTX) and GM-CSF Decrease Tumor Necrosis Factor-ALPHA (TNF-.alpha.) Levels in Patients Undergoing Allogeneic Bone Marrow Transplantation (BMT)," 1991.
Davis et al., Applied Environment Microbial., 48:2, pp. 327-331, "Microbial Models of Mammalian Metabolism: Microbial Reduction and Oxidation of Pentoxifylline," Aug. 1984.
Fuhrer et al., J. Med. Chem., vol. 27, pp. 831-836, ".beta.-Adrenergic Blocking Agents: Substituted Phenylalkanolamines. Effect of Side-Chain Length on .beta.-Blocking Potency in Vitro", 1984.
Klein J. Peter
Kumar Anil M.
Underiner Gail E.
Cebulak M.
Cell Therapeutics Inc.
Dees Jos,e G.
Faciszewski, Esq. Stephen
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