Substituted amino alcohol compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514653, 564182, 564355, 564361, A61K 31165, A61K 31135, C07C23335, C07C21520

Patent

active

057505756

ABSTRACT:
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl, alkenyl or alkynyl of up to twenty carbon atoms in length or --(CH.sub.2).sub.w R.sub.5. If R.sub.1 or R.sub.2 is --(CH.sub.2).sub.w R.sub.5, w may be an integer from one to twenty and R.sub.5 may be an hydroxyl, halo, C.sub.1-8 alkoxyl group or a substituted or unsubstituted carbocycle or heterocycle. Alternatively, R.sub.1 and R.sub.2 may jointly form a substituted or unsubstituted, saturated or unsaturated heterocycle having from four to eight carbon atoms, N being a hetero atom of the resulting heterocyle. R.sub.3 may be either hydrogen or C.sub.1-3. In the compounds, a total sum of carbon atoms comprising R.sub.1 or R.sub.2, (CH.sub.2).sub.n and (CH.sub.2).sub.m does not exceed forty. R.sub.4 is a carbocycle comprising a substituted or unsubstituted ring system, the ring system having a single ring or two fused rings, a ring comprising from three to seven ring atoms. The disclosed compounds are effective agents to inhibit undesirable responses to cell stimuli.

REFERENCES:
patent: 3124579 (1964-03-01), Yoshida et al.
patent: 3422107 (1969-01-01), Mohler et al.
patent: 3737433 (1973-06-01), Mohler et al.
patent: 4515795 (1985-05-01), Hinze et al.
patent: 4576947 (1986-03-01), Hinze et al.
patent: 4636507 (1987-01-01), Kreutzer et al.
patent: 4668786 (1987-05-01), Thiele et al.
patent: 4833146 (1989-05-01), Gebert et al.
patent: 4965271 (1990-10-01), Mandell et al.
patent: 5039666 (1991-08-01), Novick, Jr.
patent: 5096906 (1992-03-01), Mandell et al.
patent: B13737433 (1987-03-01), Mohler et al.
Fuhrer et al., ".beta.--Adrenergic Blocking Agents: Substituted Phenylalkanolamines. Effect of Side-Chain Length on .beta.Blocking Potency InVitro." J. Med. Chem. vol. 27, 1984 p. 831.
Bianco et al., Blood, 76:Supplement 1 (522), p. 133a, "Pentoxifylline (PTX) and GM-CSF Decrease Tumor Necrosis Factor-ALPHA (TNF-.alpha.) Levels in Patients Undergoing Allogeneic Bone Marrow Transplantation (BMT)," 1991.
Davis et al., Applied Environment Microbial., 48:2, pp. 327-331, "Microbial Models of Mammalian Metabolism: Microbial Reduction and Oxidation of Pentoxifylline," Aug. 1984.
Fuhrer et al., J. Med. Chem., vol. 27, pp. 831-836, ".beta.-Adrenergic Blocking Agents: Substituted Phenylalkanolamines. Effect of Side-Chain Length on .beta.-Blocking Potency in Vitro", 1984.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Substituted amino alcohol compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted amino alcohol compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted amino alcohol compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-979504

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.