Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-07
1998-10-20
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142235, 5142245, 5142268, 5142275, 5142288, 5142292, 5142305, 5142308, 5142378, 514248, 514249, 514255, 514258, 514274, 514301, 514303, 514311, 514351, 514360, 514361, 514362, 514363, 514364, 514365, 514367, 514372, 514373, 514374, 514375, 514376, 514378, 514379, 514380, 514387, 514395, 514415, 514418, 514424, 514425, 514433, 514452, 514432, 514438, 346113, 346114, 346164, 346300, 549 14, 549 50, 549 75, 549367, 549368, 544 2, 544 3, 544 5, 544 8, 544 53, 544 63, 544 65, 544 66, 544 67, 544 90, 544 91,
Patent
active
058246770
ABSTRACT:
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R.sub.1 and R.sub.2 are hydrogen, a straight or branched chain alkyl, alkenyl or alkynyl of up to twenty carbon atoms in length or --(CH.sub.2).sub.w R.sub.5. If R.sub.1 or R.sub.2 is --(CH.sub.2).sub.w R.sub.5, w may be an integer from one to twenty and R.sub.5 may be an hydroxyl, halo, C.sub.1-8 alkoxyl group or a substituted or unsubstituted carbocycle or heterocycle. Alternatively, R.sub.1 and R.sub.2 may jointly form a substituted or unsubstituted, saturated or unsaturated heterocycle having from four to eight carbon atoms, N being a hetero atom of the resulting heterocyle. R.sub.3 may be either hydrogen or C.sub.13. In the compounds, a total sum of carbon atoms comprising R.sub.1 or R.sub.2, (CH.sub.2).sub.n and (CH.sub.2).sub.m does not exceed forty. R.sub.4 is a hetorocycle comprising a substituted or unsubstituted, oxidized or reduced ring system, the ring system having a single ring or two to three fused rings, a ring comprising from three to seven ring atoms. The disclosed compounds are effective agents to inhibit undesirable responses to cell stimuli.
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Klein J. Peter
Kumar Anil M.
Underiner Gail E.
Cebulak Mary C.
Cell Therapeutics Inc.
Faciszewski, Esq. Stephen
Raymond Richard L.
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