Substituted amines as tachykinin receptor antagonists

Details Substituted amines as tachykinin receptor antagonists Substituted amines as tachykinin receptor antagonists

1995-01-27

1996-09-10

Davis, Zina Northington

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 14, 546159, 546162, 546194, 546245, 546246, 546251, 546255, 5482648, 5483701, 5483097, 5483381, 5483741, 5483751, 5483684, 5483074, 5483071, 5483717, 5483064, 548110, 548127, 548128, 548130, 548131, 548133, 548134, 548135, 548136, 548138, 548194, 548201, 548206, 548217, 548233, 548236, 548245, 548247, 548251, 548253, 548255, 5483245, 5483325, 5482676, 5483265, 5483081, 5483345, 5483094, 5483215, 5483355, 548471, 5483335, 548477, 548557, 548560, 549 4, 549 69, 549 57, 549 58, 549 77, 549467, 549480, 549

Patent

active

055546331

ABSTRACT:
Compounds of formula (I), and salts and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; X and Y are each H or together form a group=O; Z is O, S or NR.sup.9, where R.sup.9 is H or C.sub.1-6 alkyl; R.sup.1 represents H or C.sub.1-6 alkyl; R.sup.2 represents C.sub.1-6 alkyl substituted by CONR.sup.7 (CH.sub.2).sub.p R.sup.8 (where R.sup.7 is H or C.sub.1-6 alkyl, R.sup.8 is optionally substituted heteroaryl and p is 0, 1, 2, 3, 4, 5 or 6); R.sup.3 represents H, C.sub.1-6 alkyl or C.sub.2-6 alkynyl; R.sup.4 represents H, C.sub.1-6 alkyl or optionally substitute phenyl; R.sup.5 represents optionally substituted phenyl; R.sup.6 is H or C.sub.1-6 alkyl; and q is 0, 1, 2 or 3; are tachykinin antagonists useful in therapy.

REFERENCES:
patent: 5063208 (1991-11-01), Rosenberg et al.

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