Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1987-06-01
1988-10-04
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
564246, 564247, A61K 31155
Patent
active
047756950
ABSTRACT:
This invention relates to novel substituted amidinoalkoxy and amidinoalkylamino indanones and salts thereof. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, the neurological problems caused by AIDS, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections, various brain concussions, and elevated intracranial pressure.
REFERENCES:
patent: 3981911 (1976-09-01), Sletzinger
patent: 4012524 (1977-03-01), Cragoe
patent: 4070539 (1978-01-01), Cragoe
patent: 4096267 (1978-06-01), Cragoe
patent: 4247715 (1981-01-01), Johnson
patent: 4249021 (1981-02-01), Cragoe
patent: 4291050 (1981-09-01), Woltersdorf
patent: 4316043 (1982-02-01), Cragoe
patent: 4317922 (1982-03-01), Cragoe
patent: 4334088 (1982-06-01), Johnson
patent: 4337354 (1982-06-01), Cragoe
patent: 4356313 (1982-10-01), Cragoe
patent: 4356314 (1982-10-01), Cragoe
patent: 4389417 (1983-06-01), Bourke
patent: 4394385 (1983-07-01), Cragoe
patent: 4463208 (1984-07-01), Cragoe
patent: 4465850 (1984-08-01), Cragoe
patent: 4510322 (1985-04-01), Blaine
patent: 4579869 (1986-04-01), Cragoe
patent: 4604396 (1986-08-01), Cragoe
E. J. Cragoe, Jr. et al., "Agents for the Treatment of Brain Injury. 1. (Aryloxy)Alkanoic Acids," J. Med. Chem., 25, 567-579 (1982).
E. J. Cragoe, Jr. et al., "Agents for the Treatment of Brain Edema. 2. . . . ," J. Med. Chem., 29, 825-841 (1986).
O. W. Woltersdorf, Jr. et al., "(Acylaryloxy)acetic Acid Diuretics. 1. (2-Alkyl- and 2,2-Dialkyl-1-oxo-5-indanyloxy)acetic Acids," J. Med. Chem., 20, 1400-1408 (1977).
R. S. Bourke et al., "Swelling and Ion Uptake in Cat Cerebrocortical Slices: Control by Neurotransmitters and Ion Transport Mechanisms," Neurochem.Res., 8, 5-23 (1983).
E. J. Cragoe, Jr., "Drugs for the Treatment of Traumatic Brain Injury," Medicinal Research Reviews, 1, 271-305 (1987).
Cragoe, Jr. Edward J.
Woltersdorf, Jr. Otto W.
Caruso Charles M.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Reamer James H.
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