Substituted amidines having high binding to the sigma receptor a

Details Substituted amidines having high binding to the sigma receptor a Substituted amidines having high binding to the sigma receptor a

1994-01-18

1996-09-03

Burn, Brian W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514637, 564225, 564245, A61K 31155

Patent

active

055524435

ABSTRACT:
N,N'-disubstituted-amidines, e.g., of the formula ##STR1## wherein R, R' and R" are substituted or unsubstituted hydrocarbon and/or heterocyclic groups.
Methods are provided for the treatment or prophylaxis of anxiety in an animal for treating psychosis, and for treating hypertension by administering an effective amount of an N,N'-disubstituted amidine which, preferably, has a high affinity for the sigma receptor.

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