Substituted amides of 3-methyl-4-phenyl-3-butenoic acid, with a

Details Substituted amides of 3-methyl-4-phenyl-3-butenoic acid, with a Substituted amides of 3-methyl-4-phenyl-3-butenoic acid, with a

1975-06-06

1977-10-11

Wyman, Daniel E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260558R, 542438, 4242484, C07C10376, A61K 31165

Patent

active

040536351

ABSTRACT:
Amides of 3-methyl-4-phenyl-3-butenoic acid of the formula ##STR1## wherein R represents hydrogen, alkyl, hydroxyalkyl or cycloalkyl and R' represents alkyl, hydroxyalkyl or cycloalkyl, or R and R' together represent --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --CH.sub.2 --, which are obtained by reacting the chloride of 3-methyl-4-phenyl-3-butenoic acid and amines of formula ##STR2## wherein R and R' have the above indicated meanings, having a high hypolipemizing activity.

REFERENCES:
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patent: 3231469 (1966-01-01), Canonica
patent: 3245878 (1966-04-01), Berger et al.
patent: 3626005 (1971-12-01), Scheben et al.
patent: 3780102 (1973-12-01), Bayssat et al.
patent: 3824274 (1974-07-01), Franke et al.
patent: 3859338 (1975-01-01), Engel et al.
Mitsumori et al., CA 81:169330r (1974).
Valcavi, CA 81:77648x (1974).
Ohki et al., Index Chemicus 112906 (1969).
Buchi et al., J. Amer. Chem. Soc. 96 (17), pp. 5563-5565, (1974).

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