Substituted amide derivatives

Details Substituted amide derivatives Substituted amide derivatives

1996-03-15

1997-07-01

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514379, 514569, 548217, 549 77, 549467, 562427, 562444, 562449, 562450, A61K 3119, C07C22924, C07C22922

Patent

active

056439580

ABSTRACT:
The present invention relates to a compound of the formula (I): ##STR1## wherein Ar.sup.1, Ar.sup.2 and Ar.sup.3 represent an aryl group or a heteroaromatic ring group; A represents a hydrocarbon group which may be substituted; Q represents a group of the formula --(CH.sub.2).sub.m -- (m is an integer of from 1 to 6) or --(CH.sub.2).sub.n --W--(CH.sub.2).sub.p -- (W is an oxygen atom, a sulfur atom, a vinylene group or an ethynylene group; n and p are a integer of from 0 to 3); R.sup.1 represents a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an aryl or heteroaromatic ring group which may be substituted; R.sup.2, R.sup.7 and R.sup.8 represent a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a lower alkoxy group; R.sup.3 and R.sup.4 represent a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a nitro group, a cyano group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkyl group, a lower hydroxyalkyl group, a lower fluoroalkyl group or a lower alkoxy group; R.sup.5 represents a lower alkyl group; and R.sup.6 represents a hydrogen atom or a lower alkyl group, its pharmaceutically acceptable salt or ester, and an antitumor agent containing it as an active ingredient.

REFERENCES:
patent: 5260465 (1993-11-01), Singh et al.
patent: 5340828 (1994-08-01), Graham et al.
patent: 5488149 (1996-01-01), Nomoto et al.

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