Substituted amic acid derivatives

Details Substituted amic acid derivatives Substituted amic acid derivatives

1996-08-13

1998-07-07

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560183, 560185, 560186, 560187, 549229, C07C 6978, C07C 69767, C07C 69773, C07D31734

Patent

active

057771502

ABSTRACT:
A compound of the formula (I) or its pharmaceutically acceptable salt or ester: ##STR1## wherein each of ##STR2## which are the same or different, is an aryl group or a heteroaromatic ring group; A is a C.sub.3-8 linear saturated or unsaturated aliphatic hydrocarbon group which may have substituent(s) selected from the group consisting of a lower alkyl group, a hydroxyl group, a lower alkoxy group, a carboxyl group, an aryl group and an aralkyl group; Q is a single bond or a group of the formula --CO--O--, --O--CO--, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --OCH.sub.2 --, --SCH.sub.2 --, --CH.sub.2 O-- or --CH.sub.2 S--; each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 which are the same or different, is a hydrogen atom, a halogen atom, a lower alkyl group, a hydroxyl group, a lower alkoxy group, or an aryl or heteroaromatic ring group which may have substituent(s) selected from the group consisting of a halogen atom, a lower alkyl group and a lower alkoxy group; each of R.sup.5, R.sup.6 and R.sup.7 which are the same or different, is a hydrogen atom or a lower alkyl group; and R.sup.8 is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or an aralkyl group, provided that when Q is a single bond, ##STR3## are not simultaneously 4-chlorophenyl groups.

REFERENCES:
Lindell et al, Tetrahedron Letters, 31(37), pp. 5381-5384, 1990.
Kvittingen et al, Biotechnology Letters, 13(1), pp. 13-18, 1991.
Serval et al, J. Pharm. Exp. Ther., 260(3), pp. 1093-1100, 1992.

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