Substituted alkyltetraamine derivatives

Details Substituted alkyltetraamine derivatives Substituted alkyltetraamine derivatives

2000-01-05

2000-09-19

Krass, Frederick

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514617, 564134, 564139, 564142, 564144, 564153, 564155, 564158, A01N 3718

Patent

active

061213268

ABSTRACT:
Compounds which are useful as a tachykinin antagonist are substituted alkyltetraamine derivatives which are represented by the following formula (I) or a pharmaceutically acceptable salt, a complex compound or a solvate thereof. ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and each is a phenyl group which may be substituted with one or more hydroxyl, lower alkoxy and/or acyloxy group(s). The compounds are useful as an anti-inflammatory agent, anti-allergic agent, analgesic, antiemetic, agent for irritable colon syndrome, agent for dermal disease, agent for vasospastic disease, agent for cerebral ischemic disease, antidepressant, antianxiety agent, agent for autoimmune disease, antispasmodic, and as a muscle relaxant, etc.

REFERENCES:
patent: 5218000 (1993-06-01), Usherwood et al.
Jentgens et al, "Selective Synthesis of Polyamine Derivatives: Efficient Derivitazation of the Secondary Amino Group of N-Monosubstituted 1,3-Diamines", Helvetica Chimica Acta, vol. 80, pp. 966-978, Dec. 1997.
Martin-Tanguy et al, "The Distribution of Hydroxycinnamic Acid Amides in Flowering Plants", Phytochemistry 17:11, p. 1927-8, Dec. 1978.

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