Substituted alkylamide derivatives of teicoplanin

Details Substituted alkylamide derivatives of teicoplanin Substituted alkylamide derivatives of teicoplanin

1995-06-05

1996-03-19

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 530317, 530322, A61K 3808, A61K 3812, A61K 3814, C07K 900

Patent

active

055004105

ABSTRACT:
The present invention is directed to new C.sup.63 amide derivatives of teicoplanin wherein the amide moiety is derived from a di- or poly-alkylamine, and to a process for preparing them. The derivatives are prepared by reacting a teicoplanin-like product with an active ester forming reagent such as chloroacetonitrile and then contacting said active ester with the appropriate di- or poly-alkylamine. The amide derivatives of the invention are active against gram positive and gram negative bacteria.

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patent: 4629781 (1986-12-01), Strazzolini et al.
patent: 4645827 (1987-02-01), Malabarba et al.
patent: 4698418 (1987-10-01), Malabarba et al.
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patent: 5064811 (1991-11-01), Borghi et al.
Chemical Abstract, vol. 109 (1988) p. 129526z.
A. Malabarba et al., Synthesis and Biological Activity of Some Esters of the N-Acetylglucosaminyl Aglycone and of the Aglycone of Teicoplanin, J. of Antibiotics, vol. 40, No. 11, pp. 1572-1587, Nov. 1987.
Deaminoteicoplanin and Its Derivatives. Synthesis, Antibacterial Activity, and Binding Strength to AC-D-Ala-D-Ala, Aldo Trani, et al., J. Med Chem. 1989, 32, pp. 310-314.

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