Substituted alkyl amido piperidines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S193000, C546S194000

Reexamination Certificate

active

10753057

ABSTRACT:
This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety.

REFERENCES:
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patent: 6720324 (2004-04-01), Marzabadi et al.
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Connoly et al. “Preparation of 2-aminopyridines . . . ” CA 132:279120 (2000).
Chen et al. “Preparation of substituted 3,4-dihydro-4H . . . ” CA 141:123625 (2004).
Lightowler et al. “Anxiolytic like effect . . . ” Ca 121:195817 (1994).
S. Takekawa, et al., “T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist”, Eur. J. Pharmacol. 438(3), (2002) pp. 129-135.
U.S. Appl. No. 10/719,358, Marzabadi et al., filed Nov. 21, 2003, not yet published.

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