Substituted acetanilidoiminodiacetic acid compounds, diagnostic

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure

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424 15, 424 9, 564 54, 564194, A61K 4900, A61K 4300

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active

043506747

ABSTRACT:
What are disclosed are (2,3,4,5,6-pentafluoroacetanilido)-iminodiacetic acid and a method for its preparation from chloroacetic acid (2,3,4,5,6-pentafluoroanilide); (4-n-pentylacetanilido)-iminodiacetic acid and a method for its preparation from chloroacetic acid (4-n-pentylanilide); diagnostic agents for visualizing the heptobiliary system containing these substituted acetanilidoiminodiacetic acid compounds labeled with technetium-99m; and methods for making and using such diagnostic agents.

REFERENCES:
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patent: 4013716 (1977-03-01), Abblard et al.
patent: 4017596 (1977-04-01), Loberg et al.
patent: 4058557 (1977-11-01), Douglas et al.
Ju et al., Chem. Abstracts, vol. 90, Jun. 4, 1979, abstract #182407b.
Loberg et al., J. Nuc. Med., vol. 17, #7, Jul. 1976, pp. 633-638.
J. Labelled Compounds and Radiopharmaceuticals, vol. XVIII, Nos. 1-2 (1981), pp. 56-58.
Hauser et al., Radiology 94, 679-684 (1970).

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