Substituted acetamide derivatives

Details Substituted acetamide derivatives Substituted acetamide derivatives

1993-09-07

1995-04-11

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514274, 514312, 514351, 514398, 514468, 514617, 514824, 544301, 546153, 546300, 5483245, 549460, 564162, 564161, A61K 31165, C07C32323, C07C32124

Patent

active

054058732

ABSTRACT:
There are provided substituted acetamide derivatives represented by general formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, n and Z are defined in the specification. The substituted acetamide derivatives strongly inhibit acylcoenzyme A cholesterol acyltransferase (ACTA) and are expected to be effective for the treatment and prevention of hypercholesterolemia, hyperlipemia and arteriosclerosis.

REFERENCES:
patent: 4751245 (1988-06-01), Bisacchi
Krishnamurthy, S. et al., "Rapid and Selective . . . " J. Org. Chem; N.Y., 54, 1989, pp. 4458-4462.
Dickens, M. J. et al. "Transition Metal . . . " Tetrahedron, Great Britain, vol. 47, No. 40, Aug. 91, pp. 8621-8634.
Smith, J. L. "Hepatic acyl-CoA:Cholesterol . . . " Clinica Chimica Acta, Australia, 158, 1986, pp. 271-282.
Fukushima, H. et al; "The Effect of N-. . . " J. Atheroscler. Res., The Nethalands, 1969, 10:pp. 403-414.

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