Substituted 7-sulfanylmethyl-, 7-sulfinylmethyl- and...

Details Substituted 7-sulfanylmethyl-, 7-sulfinylmethyl- and... Substituted 7-sulfanylmethyl-, 7-sulfinylmethyl- and...

2009-06-24

2011-11-22

Chu, Yong (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S415000

Reexamination Certificate

active

08063234

ABSTRACT:
The present application relates to novel 7-sulfanylmethyl-, 7-sulfinylmethyl- and 7-sulfonylmethylindole derivatives, processes for the preparation thereof, the use thereof alone or in combinations for the treatment and/or prevention of diseases, and the use thereof for the manufacture of medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

REFERENCES:
patent: 2752358 (1956-06-01), Ehrhart et al.
patent: 2765320 (1956-10-01), Bader et al.
patent: 2778819 (1957-01-01), Baumann et al.
patent: 5808064 (1998-09-01), Chen et al.
patent: WO-90/05721 (1990-05-01), None
patent: WO-97/43260 (1997-11-01), None
patent: WO-98/06725 (1998-02-01), None
patent: WO-00/06568 (2000-02-01), None
patent: WO-00/06569 (2000-02-01), None
patent: WO-01/19355 (2001-03-01), None
patent: WO-01/19776 (2001-03-01), None
patent: WO-01/19778 (2001-03-01), None
patent: WO-01/19780 (2001-03-01), None
patent: WO-02/42301 (2002-05-01), None
patent: WO-02/070462 (2002-09-01), None
patent: WO-02/070510 (2002-09-01), None
patent: WO-03/095451 (2003-11-01), None
patent: WO-2004/067529 (2004-08-01), None
patent: WO-2005/092854 (2005-10-01), None
patent: WO-2005/118539 (2005-12-01), None
patent: WO-2007/040166 (2007-04-01), None
patent: WO-2007/062994 (2007-06-01), None
patent: WO-2007/070892 (2007-06-01), None
patent: WO-2008/019357 (2008-02-01), None
patent: WO-2008/157740 (2008-12-01), None
R. E. Booth et al.: “Aldosterone,” Advances in Physiology Education, vol. 26, No. 1, Mar. 2002, pp. 8-20.
B. Pitt et al.: “Eplerenone, A Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction,” The New England Journal of Medicine, vol. 348, No. 14, Apr. 3, 2003, pp. 1309-1321.
B. Pitt et al.: “The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure,” The New England Journal of Medicine, vol. 341, No. 10, pp. 709-717, (1999).
H. A. Kuhn et al.: Innere Medizin—Ein Lehrbuch fur Studierende der Medizin und Arzte Begrundet von Ludwig Heilmeyer, Springer-Verlag, Berlin, Heidelberg, New York, 1982.
M. A. Zaman et al.; “Drugs Targeting the Renin-Angiotension-Aldosterone System,” Nature Reviews Drug Discovery, vol. 1, Aug. 2002, pp. 621-636.
L. Seiler et al.: “Der Aldosteron-Renin-Quotient bei Sekundarer Hypertonie,” Herz, vol. 28, No. 8, 2003, 686-691.
J.W. Funder: “Mineralocorticoid Receptors and Cardiovascular Damage: It's Not Just Aldosterone”,Hypertension, vol. 47 (2006) pp. 634-635.
L. Weihong et al., “Steroid receptor heterodimerization demonstrated in vitro and in vivo”,Proc. Natl. Acad. Sci. USA, vol. 92, Dec. 1995, pp. 12480-12484.
M J Meyers et al., “Non-Steroidal mineralocorticoid receptor antagonists”,Expert Opin. Ther. Patents, vol. 17, No. 1, 2007, pp. 17-23.
MG Bell et al., “(S)-N-{3-[1-Cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: A Potent, Nonsteroidal, Functional Antagonist of the Mineralocorticoid Receptor”,Journal of Medicinal Chemistry, vol. 50, No. 26, 2007, pp. 6443-6445.
ML Kantam et al., “Friedel-Crafts alkylation of indoles with epoxides catalyzed by nanocrystalline titanium(IV) oxide”,Tetrahedron Letters47 (2006) pp. 6213-6216.
Y. Oikawa et al., “Meldrum's Acid in Organic Synthesis. 1. A Convenient One-Pot Synthesis of Ethyl Indolepropionates”,Tetrahedron LettersNo. 20, (1978) pp. 1759-1762.
Z. Xu et al., “N-Fluorobis[(perfluoroalkyl)sulfonyl]imides. Efficient reagents for the fluorination of 1,3-dicarbonyl derivatives”,Journal of Fluorine Chemistry, 58 (1992) pp. 71-79.
W.H. Bunnelle et al., “Difluorination of Esters. Preparation of α,α-Difluoro Ethers”,J. Org. Chem. 55 (1990) pp. 768-770.
K.R. Gassen et al. “Fluorinated Cyclopropanecarboxylic Acids and Their Derivatives”,Journal of Fluorine Chemistry, 49 (1990) pp. 127-139.
M.E. Rosenthale et al. “Determination of Antialdosterone Activity in Normal Dogs”,Proc. Soc. Exp. Biol. Med., vol. 118 (1965) pp. 806-809.

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