Substituted 7-oxomitosanes

Details Substituted 7-oxomitosanes Substituted 7-oxomitosanes

1990-02-26

1992-03-24

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

548422, C07D48714, A61K 3140

Patent

active

050990160

ABSTRACT:
The present invention provides novel mitomycin analogs containing a disulfide group and processes for the preparation thereof. These compounds are mitomycin A analogs in which the 7-alkoxy group bears an organic substituent incorporating a disulfide group. Mitomycin A is an antibiotic of established utility, and the 7-O-substituted mitosane analogs thereof have similar utility.

REFERENCES:
patent: 4888341 (1989-12-01), Remers et al.

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