Substituted 7-azaquinazoline compounds useful as p38 kinase...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S279000

Reexamination Certificate

active

10824980

ABSTRACT:
Compounds having the formula (I) or (II),are useful as p38 kinase inhibitors, wherein R is an optionally substituted alkyl, cycloalkyl, or aryl; R6is hydrogen or lower alkyl; R7is hydrogen or a non-interfering substituent, and Q is a non-aromatic moiety as defined in the specification.

REFERENCES:
patent: 3594480 (1971-07-01), Cronin et al.
patent: 4672116 (1987-06-01), Bandurco et al.
patent: 5084463 (1992-01-01), Butera et al.
patent: 6313294 (2001-11-01), Chou et al.
patent: 2002/0061879 (2002-05-01), Garvey et al.
patent: 1 110 552 (2001-06-01), None
patent: WO 92/01675 (1992-02-01), None
patent: WO 98/38984 (1998-09-01), None
patent: WO 01/32632 (2001-05-01), None
patent: WO 01/38315 (2001-05-01), None
patent: WO 01/64646 (2001-09-01), None
patent: WO 02/08224 (2002-01-01), None
patent: WO 02/085908 (2002-04-01), None
patent: WO 02/50045 (2002-06-01), None
patent: WO 02/085908 (2002-10-01), None
patent: WO/2002/090360 (2002-11-01), None
Bodor, et al., “Chemical Approaches to Drug Delivery,” Encyclopedia of Controlled Drug Delivery, 1999, John Wilery & Sons, 285-298.
Hashimoto, et al., “Seledtive Inhibitor of p38 Mitogen-Activated Protein Kinase Inhibits Lipopolysaccharide-Induced Interleukin-8 Expression in Human Pulmonary Vascular Endothelial Cells,” J. of Pharm & Exp. Therap., vol. 293, No. 2, pp. 370-375, 2000.
Hensley, et al., “p38 Kinase is Activated in the Alzheimer's Disease Brain,” J. of Neurochem., vol. No. 5, 1999, pp. 2053-2058.
Johnson, et al., “Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK and p38 Protein Kinases,” Science, vol. 298, Dec. 6, 2002, 1911-1912.
Blease, “Targeting Kinases in Asthma,” Expert Opin. Investig. Drugs, 2005, vol. 14, No. 10, 1213-1220.
Lee, et al., “p38 Mitogen-Activated Protein Kinase Inhibitors—Mechanisms and Therapeutic Potentials,” Pharmacol. Ther., May-Jun. 1999;82(2-3):389-97.
Lee, J.C., et al., “p38 Mitogen-Activated Protein Kinase Inhibitors Mechanisms and Therapeutic Potentials,”Pharmacol. Ther.82 (1999) 389-397.
Newton , R., et al., “New aspects of p38 mitogen activated kinase (MAPK) biology in lung inflammation,”Drug Discovery Today3 (2006) 53-61.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Substituted 7-azaquinazoline compounds useful as p38 kinase... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted 7-azaquinazoline compounds useful as p38 kinase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted 7-azaquinazoline compounds useful as p38 kinase... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3799173

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.