Substituted 6- and 7-aminotetrahydroisoquinolinecarboxylic acids

Details Substituted 6- and 7-aminotetrahydroisoquinolinecarboxylic acids Substituted 6- and 7-aminotetrahydroisoquinolinecarboxylic acids

1998-05-11

1999-10-05

Mach, D M

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546141, 546143, 546146, 546147, A61K 3147, A61K 31475, C07D21722, C07D21700

Patent

active

059624710

ABSTRACT:
Compounds of the formula I ##STR1## are suitable for the preparation of pharmaceuticals for the prophylaxis and therapy of disorders involving increased activity of matrix-degrading metalloproteinases.

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Chemical Abstracts 128:102014, abstract of WO 9800403, Dominianni, 1998.
chemical Abstracts 127:65701, abstract of WO 9718194, Thorwart, 1997.
Fosang et al., "Aggrecan is Degraded by Matrix Metalloproteinases in Human Arthritis," J. Clin. Invest., 98(10):2292-2299 (1996).
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