Substituted 5-phenyl-2,3,4,5-tetrahydro-1,4-benzoxazepines

Details Substituted 5-phenyl-2,3,4,5-tetrahydro-1,4-benzoxazepines Substituted 5-phenyl-2,3,4,5-tetrahydro-1,4-benzoxazepines

1977-02-04

1978-11-14

Tovar, Jose

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603265S, 260333, 424274, 424244, C07D41306, A61K 3155, C07D26714

Patent

active

041255380

ABSTRACT:
Substituted 5-phenyl-2,3,4,5-tetrahydro-1,4-benzoxazepines of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each methyl or, when taken together with the nitrogen to which they are attached, represent pyrrolidino, R.sup.3 and R.sup.4 are the same or different and represent hydrogen, chloro, fluoro, bromo, iodo, nitro, (lower)alkyl, trifluoromethyl, (lower)alkoxy, trifluoromethoxy or (lower)alkylthio, and n is an integer from 1 to 4, and their nontoxic pharmaceutically acceptable acid addition salts, are valuable analgesic and/or antitussive agents.

REFERENCES:
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H. A. Luts, Journal of Pharmaceutical Sciences 58, 1460-1463, (1969).
G. N. Walker et al., J. of Organic Chemistry 36, 305-308 (1971).
Hirohashi et al., Chemical Abstracts 73, 120697h (1970).
D. Huckle et al., J. of the Chemical Society, 1137-1141 (1965).
J. Muelberger et al., Chemical Abstracts 75, 129856m (1971).
J. Muelberger et al., Chemical Abstracts, vol. 76, 25321n, (1972).

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