Substituted 5-membered polycyclic compounds useful for...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S367400

Reexamination Certificate

active

07105559

ABSTRACT:
The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

REFERENCES:
patent: 4489096 (1984-12-01), Terao et al.
patent: 4851413 (1989-07-01), Terao et al.
patent: 4992469 (1991-02-01), Ozawa et al.
patent: 5304658 (1994-04-01), Terao et al.
patent: 5441960 (1995-08-01), Bernstein et al.
patent: 5656645 (1997-08-01), Tamura et al.
patent: 5658930 (1997-08-01), Tamura et al.
patent: 5668289 (1997-09-01), Sanderson et al.
patent: 5741819 (1998-04-01), Illig et al.
patent: 5792779 (1998-08-01), Sanderson et al.
patent: 5861380 (1999-01-01), Gyorkos et al.
patent: 5866573 (1999-02-01), Sanderson et al.
patent: 5869487 (1999-02-01), Cobum et al.
patent: 5872138 (1999-02-01), Naylor-Olsen et al.
patent: 6011158 (2000-01-01), Tamura et al.
patent: 6037356 (2000-03-01), Lu et al.
patent: 6180627 (2001-01-01), Blagg et al.
patent: 198 51 421 (2000-05-01), None
patent: 0 354 495 (1990-02-01), None
patent: 0 528 633 (1993-02-01), None
patent: 0 826 671 (1998-03-01), None
patent: 0 936 216 (1999-08-01), None
patent: 0 940 400 (1999-09-01), None
patent: 0 997 474 (2000-05-01), None
patent: WO 93/21214 (1993-10-01), None
patent: WO 96/18644 (1996-06-01), None
patent: WO 96/33974 (1996-10-01), None
patent: WO 96/39380 (1996-12-01), None
patent: WO 96/40100 (1996-12-01), None
patent: WO 97/01338 (1997-01-01), None
patent: WO 97/30708 (1997-08-01), None
patent: WO 97/40024 (1997-10-01), None
patent: WO 97/46207 (1997-12-01), None
patent: WO 98/08840 (1998-03-01), None
patent: WO 98/09949 (1998-03-01), None
patent: WO 98/09987 (1998-03-01), None
patent: WO 98/10763 (1998-03-01), None
patent: WO 98/16525 (1998-04-01), None
patent: WO 98/16547 (1998-04-01), None
patent: WO 98/17274 (1998-04-01), None
patent: WO 98/28282 (1998-07-01), None
patent: WO 98/31670 (1998-07-01), None
patent: WO 98/42342 (1998-10-01), None
patent: WO 98/47876 (1998-10-01), None
patent: WO 98/50420 (1998-11-01), None
patent: WO 99/00121 (1999-01-01), None
patent: WO 99/00126 (1999-01-01), None
patent: WO 99/00128 (1999-01-01), None
patent: WO 99/11267 (1999-03-01), None
patent: WO 99/26920 (1999-06-01), None
patent: WO 99/26926 (1999-07-01), None
patent: WO 99/36426 (1999-07-01), None
patent: WO 99/43660 (1999-09-01), None
patent: WO 99/48892 (1999-09-01), None
patent: WO 99/59591 (1999-11-01), None
patent: WO 99/61442 (1999-12-01), None
patent: WO 99/62538 (1999-12-01), None
patent: WO 99/64446 (1999-12-01), None
patent: WO 01/18762 (2000-04-01), None
patent: WO 00/26210 (2000-05-01), None
patent: WO 00/26211 (2000-05-01), None
patent: WO 00/32574 (2000-06-01), None
patent: WO 00/39102 (2000-07-01), None
patent: WO 00/42059 (2000-07-01), None
patent: WO 00/69826 (2000-11-01), None
patent: WO 00/69832 (2000-11-01), None
patent: WO 00/69833 (2000-11-01), None
patent: WO 00/69834 (2000-11-01), None
patent: WO 01/77097 (2001-10-01), None
patent: WO 02/22575 (2002-03-01), None
Coburn, C.A., “Small-molecule direct thrombine inhibitors 1997-2000.” Expert Opinions on Therapeutic Patents, 2001, 721-738, vol. 11, No. 5.
XP-002182132—Darvas, et al., “Investigation of the Common Mechanism of Action of Antibacterial Compounds Containing .gamma.-pyridone-.beta.-carboxylic acid Structure by Principal Component.” Arzneim.-Forshc., 1979, pp. 1334-1339, vol. 29, 9.
Handin, R., “Bleeding and Thrombosis.” Harrison's Principles of Internal Medicine, 12th Edition, 1991, pp. 348-353, McGraw-Hill, Inc., New York.
XP-002172033—Kohama et al., “The Preparation of Piperidinyloxyacetylaminobenzoylalanine Derivatives and Analogs as Antithrombotics.” JP 07,233,148.
Majerus, et al. “Anticoagulant, Thrombolytic, and Antiplatlet Drugs.” Goodman & Gilman's The Pharmacological Basis of Therapeutics, Ninth Edition, 1996, pp. 1341-1359, McGraw-Hill, New York.
XP-002187583—Moerner, Hoppe-Seyler's Z. Physiol. Chem., 69, 1910;357.
Patel et al., “Directed Aminomethylation of 3-Hydroxy-3(1H)-pyridinones and 3-hydroxy-4(1H)-pyridinones: Synthesis of iso-Deferiprone.” Tetrahedron, 1996, pp. 1835-1840, vol. 52, No. 5.
Rauch et al., “Thrombus Formulation on Atheroscleratic Plaques: Pathogenesis and Clinical Consequences.” Animals of internal Medicine, 2001, pp. 224-233, vol. 134, No. 3.
Sanderson et al., “L-373,890, An Achiral, Noncovalent, Subnamomolar Thrombin Inhibitor.” Bioorganic & Medicinal Chemistry Letters, vol. 7, No. 12, pp. 1497-1500, 1997.
XP-002182410—Trecourt et al., “First Synthesis of (+−)-harzianopyridone by Metalation of Polysubstituted O-pyridylcarbamates.” J. Heterocycl. Chem., 1995, pp. 1117-1114, vol. 32, No. 4.
Tulinsky et al., “Novel Asymmetric Synthesis of Atropisomeric 6-Aryl Pyrazinones via an Unusual Chirality Transfer Process.” J. Org. Chem., 1999, pp. 93-100, vol. 64, No. 1.
Van Aken, et al., “Anticoagulation: The Present and Future.” Clin. Appl. Thromiosis/Hemostasis, 2001, vol. 7, No. 3.
International Search Report, PCT/US02/31770, dated Nov. 27, 2003.

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