Substituted 5-(2-(2-aryl-2-hydroxyethyl)-amino)propyl)-1,3-benzo

Details Substituted 5-(2-(2-aryl-2-hydroxyethyl)-amino)propyl)-1,3-benzo Substituted 5-(2-(2-aryl-2-hydroxyethyl)-amino)propyl)-1,3-benzo

1992-06-10

1993-09-14

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31744

Patent

active

052450538

ABSTRACT:
A process is disclosed for obtaining the R,R isomer of: ##STR1## wherein R.sub.1 and R.sub.2 may be one or more groups which may be the same or different and are selected from the group consisting of hydrogen, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, hydroxy, halogen, trifluoromethyl, carboxy, hydroxyalkyl, alkoxycarbonyl, C.sub.1 to C.sub.4 thioalkyl, sulfonyl and sulfinyl; X is a divalent radical consisting of ##STR2## wherein R' is hydrogen; R.sub.2 and R.sub.3 may be the same or different and are selected from the group consisting of hydrogen and C.sub.1 to C.sub.4 alkyl; R.sub.5 and R.sub.6 are selected from the group consisting of hydrogen, carboxy, alkoxycarbonyl, hydroxymethyl, --CH.sub.2 OCH.sub.2 COOR.sub.7 and --CH.sub.2 OCH.sub.2 CH.sub.2 OR.sub.7 where R.sub.7 is hydrogen or C.sub.1 to .sub.4 alkyl; except that R.sub.5 and R.sub.6 may not both be hydrogen; and the asterisks denote asymmetric carbon atoms; said process comprising the steps of:

REFERENCES:
patent: 3523954 (1970-08-01), Koppe et al.
patent: 4276304 (1981-06-01), Ikezaki et al.
patent: 4472427 (1984-09-01), Baldwin
patent: 4959472 (1990-09-01), Wood
patent: 5106867 (1992-04-01), Bloom et al.
patent: 5110956 (1992-05-01), Ogata et al.

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